Students who have successfully completed this course in-person have described it as a survey class on sleep that is team taught by experts.
The objective of this course is to give students the most up-to-the-date
information on the biological, personal, and societal relevance of sleep.
Personal relevance is emphasized by the fact that the single best predictor
of daytime performance is the quality of the previous night's sleep. The
brain actively generates sleep, and the first third of the course will
overview the neurobiological basis of sleep cycle control. The course provides
a cellular-level understanding of how sleep deprivation, jet lag, and substances
such as alcohol, caffeine, and nicotine alter sleep and wakefulness. The
second third of the course will cover sleep-dependent changes in physiology
and sleep disorders medicine. Particular emphasis will be placed on disorders
of excessive sleepiness, insomnia, and sleep-dependent changes in autonomic
control. Chronic sleep deprivation impairs immune function and may promote
obesity. Deaths due to all causes are most frequent between 4:00 and 6:00
A.M., and the second portion of the class will highlight the relevance
of sleep for preventive medicine. The societal relevance of sleep will
be considered in the final portion of the class. In an increasingly complex
and technologically oriented society, operator-error by one individual
can have a disastrous negative impact on public health and safety. Fatigue-related
performance decrements are known to have contributed as causal factors
to nuclear power plant failures, transportation disasters, and medical
Section I – Neurobiology
Unit 01 - Course Overview - Ralph Lydic, Ph.D.
Unit 02 - Neurobiology of Sleep and Wakefulness - Helen Baghdoyan, Ph.D.
Unit 03 - Mathematical Modeling of Sleep-Wake Regulation - Victoria Booth, Ph.D.
Unit 04 - Molecular Biology and Genetics of Sleep - Chiara Cirelli, M.D., Ph.D.Section II – Medicine
Unit 05 - Overview of Sleep Medicine - Ronald Chervin, M.D.
Unit 06 - Disordered Sleep and Breathing Alters Cardiovascular Health - Helena Schotland, M.D.
Unit 07 - Sleep and Psychiatric Disorders - Eric Nofzinger, M.D.
Unit 08 - Insomnia: Causes and Consequences - Christopher Drake, Ph.D.
Unit 09 - Treatments for Insomnia - J. Todd Arnedt, Ph.D.
Unit 10 - Sleep and Anesthesia - George Mashour, M.D.Section III – Society
Unit 11 - Circadian Rhythms, Sleep, and Health - Theresa Lee, Ph.D.
Unit 12 - Daytime Sleepiness and Sleep Need - Thomas Roth, Ph.D.
The topic of sleep is an ideal vehicle for teaching neuroanatomy, neurochemistry,
pharmacology, physiology, and cognitive neuroscience. Based on more than
10 years of experience with the traditional classroom setting, students
who do well in the course are up to date on basic biology, chemistry, and
Please see Course Syllabus
Video format will include lecturer presentations illustrated by still
or video images. Each lecture will begin with a list of key learning points.
The class content is divided into three sections, which are comprised of a total of twelve units. Units 2-12 conclude with a quiz. The material in the sleep neurobiology section of the
class demonstrates that sleep is not a passive process but is actively
generated by the brain. The material emphasizes the excitement of efforts
in neuroscience to understand the brain regions and neurotransmitters that
regulate states of sleep and wakefulness and circadian rhythms. The course
then builds on the neurobiology section by focusing on sleep disorders
medicine. Particular emphasis will be placed on common sleep disorders
such as sleep-disordered breathing, the relationship between sleep and
mental health, and sleep and learning. The final lectures focus on sleep
need, insomnia, the genetics of sleep, and how progress in our understanding
that sleep is a fundamental biological need has significant social and
Q: In what language will the course be presented?
Q: Will the University of Michigan document completion of this class?
A: Students who complete the class and the quizzes will receive a statement of accomplishment.
Q: Will there be an opportunity to interact with the Professors?
A: The course directors will manage a blog to address questions common
to each topic
Q: What is the potential gain any student can expect from mastering the
content in this class?
A: Available data are absolutely clear that sleep, diet, and exercise
are three modifiable factors that contribute to the divide between health
and disease. Thus, the content of this course is personally as well as